4GEE
Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Summary for 4GEE
Entry DOI | 10.2210/pdb4gee/pdb |
Related | 4GFN 4GGL 4HXW 4HXZ 4HY1 4HYM 4HYP 4HZ0 4HZ5 |
Descriptor | DNA gyrase subunit B, (1R,5S,6s)-3-[5-chloro-6-ethyl-2-(pyrimidin-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-amine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna rings, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Enterococcus faecalis |
Cellular location | Cytoplasm (By similarity): Q839Z1 |
Total number of polymer chains | 1 |
Total formula weight | 24299.53 |
Authors | Bensen, D.C.,Chen, Z.,Tari, L.W. (deposition date: 2012-08-01, release date: 2013-02-13, Last modification date: 2024-02-28) |
Primary citation | Tari, L.W.,Trzoss, M.,Bensen, D.C.,Li, X.,Chen, Z.,Lam, T.,Zhang, J.,Creighton, C.J.,Cunningham, M.L.,Kwan, B.,Stidham, M.,Shaw, K.J.,Lightstone, F.C.,Wong, S.E.,Nguyen, T.B.,Nix, J.,Finn, J. Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23:1529-1536, 2013 Cited by PubMed: 23352267DOI: 10.1016/j.bmcl.2012.11.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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