4HYP
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Summary for 4HYP
Entry DOI | 10.2210/pdb4hyp/pdb |
Related | 4GEE 4GFN 4GGL 4HXW 4HXZ 4HY1 4HYM 4HZ0 4HZ5 |
Descriptor | DNA gyrase subunit B, N-[7-(1H-imidazol-1-yl)-2-(pyridin-3-yl)[1,3]thiazolo[5,4-d]pyrimidin-5-yl]cyclopropanecarboxamide, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | gyrase, gyrb, atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Escherichia coli |
Cellular location | Cytoplasm (Potential): P0AES6 |
Total number of polymer chains | 4 |
Total formula weight | 96953.89 |
Authors | Bensen, D.C.,Creighton, C.J.,Tari, L.W. (deposition date: 2012-11-13, release date: 2013-02-13, Last modification date: 2024-02-28) |
Primary citation | Tari, L.W.,Trzoss, M.,Bensen, D.C.,Li, X.,Chen, Z.,Lam, T.,Zhang, J.,Creighton, C.J.,Cunningham, M.L.,Kwan, B.,Stidham, M.,Shaw, K.J.,Lightstone, F.C.,Wong, S.E.,Nguyen, T.B.,Nix, J.,Finn, J. Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23:1529-1536, 2013 Cited by PubMed: 23352267DOI: 10.1016/j.bmcl.2012.11.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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