Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4HYP

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Summary for 4HYP
Entry DOI10.2210/pdb4hyp/pdb
Related4GEE 4GFN 4GGL 4HXW 4HXZ 4HY1 4HYM 4HZ0 4HZ5
DescriptorDNA gyrase subunit B, N-[7-(1H-imidazol-1-yl)-2-(pyridin-3-yl)[1,3]thiazolo[5,4-d]pyrimidin-5-yl]cyclopropanecarboxamide, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsgyrase, gyrb, atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological sourceEscherichia coli
Cellular locationCytoplasm (Potential): P0AES6
Total number of polymer chains4
Total formula weight96953.89
Authors
Bensen, D.C.,Creighton, C.J.,Tari, L.W. (deposition date: 2012-11-13, release date: 2013-02-13, Last modification date: 2024-02-28)
Primary citationTari, L.W.,Trzoss, M.,Bensen, D.C.,Li, X.,Chen, Z.,Lam, T.,Zhang, J.,Creighton, C.J.,Cunningham, M.L.,Kwan, B.,Stidham, M.,Shaw, K.J.,Lightstone, F.C.,Wong, S.E.,Nguyen, T.B.,Nix, J.,Finn, J.
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23:1529-1536, 2013
Cited by
PubMed: 23352267
DOI: 10.1016/j.bmcl.2012.11.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon