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4HYM

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Summary for 4HYM
Entry DOI10.2210/pdb4hym/pdb
Related4GEE 4GFN 4GGL 4HXZ 4HY1 4HYP 4HZ0 4HZ5
DescriptorTopoisomerase IV, subunit B, 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)pyrido[2,3-b]pyrazin-2(1H)-one (3 entities in total)
Functional Keywordsatp-binding, nucleotide-binding, topoisomerase, atp-binding domain, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological sourceFrancisella tularensis subsp. holarctica LVS
Total number of polymer chains2
Total formula weight88344.46
Authors
Bensen, D.C.,Creighton, C.J.,Kwan, B.,Tari, L.W. (deposition date: 2012-11-13, release date: 2013-02-13, Last modification date: 2024-02-28)
Primary citationTari, L.W.,Trzoss, M.,Bensen, D.C.,Li, X.,Chen, Z.,Lam, T.,Zhang, J.,Creighton, C.J.,Cunningham, M.L.,Kwan, B.,Stidham, M.,Shaw, K.J.,Lightstone, F.C.,Wong, S.E.,Nguyen, T.B.,Nix, J.,Finn, J.
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23:1529-1536, 2013
Cited by
PubMed: 23352267
DOI: 10.1016/j.bmcl.2012.11.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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