4HYM

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005694	cellular_component	chromosome
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005694	cellular_component	chromosome
B	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CJC A 401

Chain	Residue
A	ILE38
A	ARG131
A	THR162
A	ILE164
A	HOH526
A	HOH530
A	HOH675
A	HOH791
A	HOH842
A	ASN41
A	SER42
A	GLU45
A	ASP68
A	GLY72
A	MET73
A	ILE89
A	VAL115

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00938

Chain	Residue	Details
A	TYR4
B	LYS333
A	ASN41
A	ASP68
A	GLY109
A	LYS333
B	TYR4
B	ASN41
B	ASP68
B	GLY109

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