4KTN

Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor ((3S)-1-[2-(PYRIDO[2,3-B]PYRAZIN-7-YLSULFANYL)-9H-PYRIMIDO[4,5-B]INDOL-4-YL]PYRROLIDIN-3-AMINE)

Summary for 4KTN

• Entry DOI: 10.2210/pdb4ktn/pdb
• Related: 4K4O 4KFG 4KQV 4KSG 4KSH
• Descriptor: DNA gyrase subunit B, (3S)-1-[2-(pyrido[2,3-b]pyrazin-7-ylsulfanyl)-9H-pyrimido[4,5-b]indol-4-yl]pyrrolidin-3-amine (3 entities in total)
• Functional Keywords: cytosol, nucleotide-binding, topoisomerase, atp-binding, dna girase closed circular double-stranded dna, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Enterococcus faecalis
• Cellular location: Cytoplasm (By similarity): Q839Z1
• Total number of polymer chains: 1
• Total formula weight: 24250.10

Authors

Bensen, D.C.,Akers-rodriguez, S.,Tari, L.W. (deposition date: 2013-05-20, release date: 2014-01-15, Last modification date: 2024-02-28)

• Primary citation: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

Experimental method

X-RAY DIFFRACTION (1.69 Å)