4KFG

The DNA Gyrase B ATP binding domain of Escherichia coli in complex with a small molecule inhibitor.

Summary for 4KFG

• Entry DOI: 10.2210/pdb4kfg/pdb
• Related: 4K4O
• Descriptor: DNA gyrase subunit B, SULFATE ION, 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, ... (4 entities in total)
• Functional Keywords: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Escherichia coli
• Cellular location: Cytoplasm (Potential): P0AES6
• Total number of polymer chains: 2
• Total formula weight: 48858.67

Authors

Bensen, D.C.,Akers-Rodriguez, S.,Lam, T.,Tari, L.W. (deposition date: 2013-04-26, release date: 2014-01-15, Last modification date: 2023-09-20)

• Primary citation: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type IIA topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)