4KFG
The DNA Gyrase B ATP binding domain of Escherichia coli in complex with a small molecule inhibitor.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | PRO79 |
| A | THR80 |
| A | GLY81 |
| A | ARG136 |
| A | GLU137 |
| A | HOH511 |
| A | HOH534 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | GLY113 |
| A | HIS116 |
| A | HOH454 |
| A | HOH505 |
| A | HOH531 |
| A | HOH544 |
| A | HOH571 |
| B | GLY113 |
| B | ARG190 |
| A | VAL111 |
| A | SER112 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DOO A 303 |
| Chain | Residue |
| A | ASN46 |
| A | GLU50 |
| A | VAL71 |
| A | ASP73 |
| A | ARG76 |
| A | GLY77 |
| A | ILE78 |
| A | PRO79 |
| A | MET91 |
| A | VAL120 |
| A | THR165 |
| A | HOH404 |
| A | HOH434 |
| A | HOH535 |
| A | HOH564 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | PRO79 |
| B | THR80 |
| B | GLY81 |
| B | ARG136 |
| B | GLU137 |
| B | HOH483 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DOO B 302 |
| Chain | Residue |
| B | ASN46 |
| B | ASP49 |
| B | GLU50 |
| B | VAL71 |
| B | ASP73 |
| B | ARG76 |
| B | GLY77 |
| B | ILE78 |
| B | VAL120 |
| B | THR165 |
| B | HOH405 |
| B | HOH414 |
| B | HOH445 |
| B | HOH536 |
| B | HOH546 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor (ATPase activity)","evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8248233","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25202966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
