4KSG

Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1S,5R,6R)-6-AMINO-1-METHYL-3-AZABICYCLO[3.2.0]HEPT-3-YL]-6-FLUORO-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE)

Summary for 4KSG

• Entry DOI: 10.2210/pdb4ksg/pdb
• Related: 4GEE 4K40 4K4O 4KFG 4KQV
• Descriptor: DNA gyrase subunit B, 4-[(1S,5R,6R)-6-amino-1-methyl-3-azabicyclo[3.2.0]hept-3-yl]-6-fluoro-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, TERTIARY-BUTYL ALCOHOL, ... (4 entities in total)
• Functional Keywords: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Enterococcus faecalis
• Cellular location: Cytoplasm (By similarity): Q839Z1
• Total number of polymer chains: 1
• Total formula weight: 24358.23

Authors

Bensen, D.C.,Akers-Rodriguez, S.,Tari, L.W. (deposition date: 2013-05-17, release date: 2014-01-15, Last modification date: 2024-02-28)

• Primary citation: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)