4J14
Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
Summary for 4J14
Entry DOI | 10.2210/pdb4j14/pdb |
Related | 3MDM 3MDR 3MDT 3MDV 4ENH 4FIA |
Descriptor | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (5 entities in total) |
Functional Keywords | enzyme, p450, posaconazole, oxidoreductase, endoplasmic reticulum, cholesterol 24-hydroxylase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2 |
Total number of polymer chains | 1 |
Total formula weight | 53534.44 |
Authors | Stout, C.D.,Mast, N.,Pikuleva, I.A. (deposition date: 2013-01-31, release date: 2014-01-15, Last modification date: 2023-09-20) |
Primary citation | Mast, N.,Zheng, W.,Stout, C.D.,Pikuleva, I.A. Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Mol.Pharmacol., 84:86-94, 2013 Cited by PubMed: 23604141DOI: 10.1124/mol.113.085902 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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