4J14
Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cholesterol 24-hydroxylase | polymer | 456 | 52125.1 | 1 | UniProt (Q9Y6A2) Pfam (PF00067) | Homo sapiens (human) | CH24H, Cytochrome P450 46A1 |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | POSACONAZOLE | non-polymer | 700.8 | 1 | Chemie (X2N) PubChem (22875880) PubChem (176477119) PubChem (21309251) PubChem (22875881) PubChem (21910730) PubChem (22875877) PubChem (24859194) PubChem (58649001) PubChem (59047101) PubChem (69944315) PubChem (70795732) PubChem (89744654) PubChem (90338708) PubChem (94865929) PubChem (124600647) PubChem (129011664) PubChem (129011666) PubChem (129132263) PubChem (134814112) PubChem (143880161) PubChem (57417226) PubChem (12010394) PubChem (138572818) PubChem (146270092) PubChem (58756608) PubChem (171380465) PubChem (94865927) PubChem (94865928) PubChem (118703725) PubChem (123334345) PubChem (147912) PubChem (124671302) PubChem (468595) PubChem (129010329) PubChem (129011665) PubChem (129011667) PubChem (129011668) PubChem (11520437) PubChem (11542142) PubChem (144360897) PubChem (169544619) PubChem (175673747) PubChem (175673756) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | E (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 51 - 500 (UniProt: Q9Y6A2)
| PDB | External Database | Details |
|---|---|---|
| Met 49 | - | expression tag |
| Ala 50 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52125.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1409.4 | |
| All* | Total formula weight | 53534.4 |
