4J14
Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cholesterol 24-hydroxylase | polymer | 456 | 52125.1 | 1 | UniProt (Q9Y6A2) Pfam (PF00067) | Homo sapiens (human) | CH24H, Cytochrome P450 46A1 |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | POSACONAZOLE | non-polymer | 700.8 | 1 | Chemie (X2N) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 51 - 500 (UniProt: Q9Y6A2)
| PDB | External Database | Details |
|---|---|---|
| Met 49 | - | expression tag |
| Ala 50 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52125.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1409.4 | |
| All* | Total formula weight | 53534.4 |
