4B95
pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound
Summary for 4B95
Entry DOI | 10.2210/pdb4b95/pdb |
Related | 1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B9K |
Descriptor | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, ... (6 entities in total) |
Functional Keywords | transcription, hypoxia inducible factor, hif-1alpha inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus : Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337 |
Total number of polymer chains | 12 |
Total formula weight | 172930.85 |
Authors | Buckley, D.L.,Gustafson, J.L.,VanMolle, I.,Roth, A.G.,SeopTae, H.,Gareiss, P.C.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M. (deposition date: 2012-08-31, release date: 2012-10-24, Last modification date: 2024-05-01) |
Primary citation | Buckley, D.L.,Gustafson, J.L.,Van Molle, I.,Roth, A.G.,Tae, H.S.,Gareiss, P.C.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M. Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1Alpha Angew.Chem.Int.Ed.Engl., 51:11463-, 2012 Cited by PubMed: 23065727DOI: 10.1002/ANIE.201206231 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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