4AJY

von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide

Summary for 4AJY

Entry DOI	10.2210/pdb4ajy/pdb
Related	1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN
Descriptor	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, ... (6 entities in total)
Functional Keywords	e3 ubiquitin ligase, transcription factor, hypoxic signaling, transcription
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Nucleus (Probable): Q15370 Q15369 Cytoplasm: Q16665 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	4
Total formula weight	45315.39
Authors	Van Molle, I.,Thomann, A.,Buckley, D.L.,So, E.C.,Lang, S.,Crews, C.M.,Ciulli, A. (deposition date: 2012-02-21, release date: 2012-11-14, Last modification date: 2023-12-20)
Primary citation	Van Molle, I.,Thomann, A.,Buckley, D.L.,So, E.C.,Lang, S.,Crews, C.M.,Ciulli, A. Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Chem.Biol., 19:1300-, 2012 Cited by PubMed: 23102223 DOI: 10.1016/J.CHEMBIOL.2012.08.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation