4AJY

von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	118	13147.8	1	UniProt (Q15370) Pfam (PF00240)	HOMO SAPIENS (HUMAN)	ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18
2	B (C)	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1	polymer	97	10974.6	1	UniProt (Q15369) Pfam (PF03931)	HOMO SAPIENS (HUMAN)	ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15
3	C (H)	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA	polymer	19	2260.5	1	UniProt (Q16665) Pfam (PF11413)	HOMO SAPIENS	HIF-1-ALPHA, HIF1-ALPHA, ARNT-INTERACTING PROTEIN, BASIC-HELIX-LOOP-HELIX-PAS PROTEIN MOP1, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 78, BHLHE78, MEMBER OF PAS PROTEIN 1, PAS DOMAIN-CONTAINING PROTEIN 8
4	D (V)	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR	polymer	163	18840.4	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	HOMO SAPIENS (HUMAN)	PROTEIN G7, PVHL, PVHL54-213
5	E (V)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	F, G, H, I (B, C, H, V)	water	water		18.0	242	Chemie (HOH)

Sequence modifications

C: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	expression tag

H: 559 - 577 (UniProt: Q16665)

PDB	External Database	Details
Asp 559	Leu 559	engineered mutation
Ala 561	Met 561	engineered mutation

V: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	45223.3
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	45315.4

*Water molecules are not included.