3ZRF

pVHL54-213-EloB-EloC complex_apo

Summary for 3ZRF

Entry DOI	10.2210/pdb3zrf/pdb
Related	1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRC
Descriptor	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR,, ... (4 entities in total)
Functional Keywords	transcription, tumour supressor protein, chronic aneamia treatment, e3 ubiquitin ligase
Biological source	HOMO SAPIENS More
Cellular location	Nucleus (Probable): Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	12
Total formula weight	171851.34
Authors	Van Molle, I.,Buckley, D.L.,Crews, C.M.,Ciulli, A. (deposition date: 2011-06-16, release date: 2012-03-07, Last modification date: 2023-12-20)
Primary citation	Buckley, D.L.,Van Molle, I.,Gareiss, P.C.,Tae, H.S.,Michel, J.,Noblin, D.J.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M. Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134:4465-, 2012 Cited by PubMed: 22369643 DOI: 10.1021/JA209924V PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation