3ZRF
pVHL54-213-EloB-EloC complex_apo
Summary for 3ZRF
Entry DOI | 10.2210/pdb3zrf/pdb |
Related | 1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRC |
Descriptor | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR,, ... (4 entities in total) |
Functional Keywords | transcription, tumour supressor protein, chronic aneamia treatment, e3 ubiquitin ligase |
Biological source | HOMO SAPIENS More |
Cellular location | Nucleus (Probable): Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337 |
Total number of polymer chains | 12 |
Total formula weight | 171851.34 |
Authors | Van Molle, I.,Buckley, D.L.,Crews, C.M.,Ciulli, A. (deposition date: 2011-06-16, release date: 2012-03-07, Last modification date: 2023-12-20) |
Primary citation | Buckley, D.L.,Van Molle, I.,Gareiss, P.C.,Tae, H.S.,Michel, J.,Noblin, D.J.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M. Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134:4465-, 2012 Cited by PubMed: 22369643DOI: 10.1021/JA209924V PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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