3ZRF

pVHL54-213-EloB-EloC complex_apo

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0001222	molecular_function	transcription corepressor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016567	biological_process	protein ubiquitination
A	0030891	cellular_component	VCB complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0065003	biological_process	protein-containing complex assembly
A	0070449	cellular_component	elongin complex
A	0140958	biological_process	target-directed miRNA degradation
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0000151	cellular_component	ubiquitin ligase complex
D	0001222	molecular_function	transcription corepressor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0016567	biological_process	protein ubiquitination
D	0030891	cellular_component	VCB complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0065003	biological_process	protein-containing complex assembly
D	0070449	cellular_component	elongin complex
D	0140958	biological_process	target-directed miRNA degradation
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0000151	cellular_component	ubiquitin ligase complex
G	0001222	molecular_function	transcription corepressor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016567	biological_process	protein ubiquitination
G	0030891	cellular_component	VCB complex
G	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
G	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0065003	biological_process	protein-containing complex assembly
G	0070449	cellular_component	elongin complex
G	0140958	biological_process	target-directed miRNA degradation
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0000151	cellular_component	ubiquitin ligase complex
J	0001222	molecular_function	transcription corepressor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0016567	biological_process	protein ubiquitination
J	0030891	cellular_component	VCB complex
J	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
J	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0065003	biological_process	protein-containing complex assembly
J	0070449	cellular_component	elongin complex
J	0140958	biological_process	target-directed miRNA degradation
K	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	260
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	220
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

---