4B95

pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	118	13147.8	4	UniProt (Q15370) Pfam (PF00240) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18
2	B, E, H, K	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15
3	C, F, I, L	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR	polymer	162	18702.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	HOMO SAPIENS (HUMAN)	PROTEIN G7, PVHL
4	B	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	C, F, I, L	(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		393.3	4	Chemie (UCK)
6		water	water		18.0	193	Chemie (HOH)

Sequence modifications

B, E, H, K: 18 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	expression tag
Met 17	-	expression tag

C, F, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	171298.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1632.1
All*	Total formula weight	172930.9

*Water molecules are not included.