3S3M

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and Dolutegravir (S/GSK1349572)

Summary for 3S3M

• Entry DOI: 10.2210/pdb3s3m/pdb
• Related: 3L2U 3OY9 3OYA 3OYB 3OYK 3OYL 3OYM 3OYN 3S3N 3S3O
• Descriptor: PFV integrase, HEXANE-1,6-DIOL, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', ... (11 entities in total)
• Functional Keywords: protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, recombination-inhibitor-dna complex, recombination/inhibitor/dna
• Biological source: Human spumaretrovirus (SFVcpz(hu), Human foamy virus); More
• Cellular location: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• Total number of polymer chains: 4
• Total formula weight: 101173.70

Authors

Hare, S.,Cherepanov, P. (deposition date: 2011-05-18, release date: 2011-07-13, Last modification date: 2023-09-13)

• Primary citation: Hare, S.,Smith, S.J.,Metifiot, M.,Jaxa-Chamiec, A.,Pommier, Y.,Hughes, S.H.,Cherepanov, P.; Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).; Mol.Pharmacol., 80:565-572, 2011; PubMed: 21719464; DOI: 10.1124/mol.111.073189

Experimental method

X-RAY DIFFRACTION (2.49 Å)