3L2U

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and GS9137 (Elvitegravir)

Summary for 3L2U

• Entry DOI: 10.2210/pdb3l2u/pdb
• Related: 3DLR 3L2Q 3L2R 3L2S 3L2T 3L2V 3L2W
• Descriptor: Integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ... (8 entities in total)
• Functional Keywords: protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, zinc, dna-binding, zinc binding, hhcc motif, viral protein, recombination, recombination-dna complex, recombination/dna
• Biological source: Human spumaretrovirus (SFVcpz(hu))
• Cellular location: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• Total number of polymer chains: 4
• Total formula weight: 100914.23

Authors

Hare, S.,Gupta, S.S.,Cherepanov, P. (deposition date: 2009-12-15, release date: 2010-02-09, Last modification date: 2023-11-01)

• Primary citation: Hare, S.,Gupta, S.S.,Valkov, E.,Engelman, A.,Cherepanov, P.; Retroviral intasome assembly and inhibition of DNA strand transfer; Nature, 464:232-236, 2010; PubMed: 20118915; DOI: 10.1038/nature08784

Experimental method

X-RAY DIFFRACTION (3.15 Å)