3OYM

Crystal structure of the PFV N224H mutant intasome bound to manganese

Summary for 3OYM

Related3DLR 3L2Q 3L2R 3L2U 3L2V 3L2W 3OY9 3OYA 3OYB 3OYC 3OYD 3OYE 3OYF 3OYG 3OYH 3OYI 3OYJ 3OYK 3OYL 3OYN
DescriptorPFV integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total)
Functional Keywordsprotein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, dna-binding protein-dna complex, viral protein-dna complex, viral protein/dna
Biological sourceHuman spumaretrovirus (SFVcpz(hu))
More
Cellular locationIntegrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity) P14350
Total number of polymer chains4
Total molecular weight101106.76
Authors
Hare, S.,Cherepanov, P. (deposition date: 2010-09-23, release date: 2010-11-17, Last modification date: 2011-07-13)
Primary citation
Hare, S.,Vos, A.M.,Clayton, R.F.,Thuring, J.W.,Cummings, M.D.,Cherepanov, P.
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA, 107:20057-20062, 2010
PubMed: 21030679 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1010246107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.02 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.227501.8%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution