3L2V
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and MK0518 (Raltegravir)
Summary for 3L2V
Entry DOI | 10.2210/pdb3l2v/pdb |
Related | 3DLR 3L2Q 3L2R 3L2S 3L2T 3L2U 3L2W |
Descriptor | Integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ... (8 entities in total) |
Functional Keywords | protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, zinc, dna-binding, zinc binding, hhcc motif, viral protein, recombination, recombination-dna complex, recombination/dna |
Biological source | Human spumaretrovirus (SFVcpz(hu)) |
Cellular location | Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350 |
Total number of polymer chains | 4 |
Total formula weight | 101002.66 |
Authors | Hare, S.,Gupta, S.S.,Cherepanov, P. (deposition date: 2009-12-15, release date: 2010-02-09, Last modification date: 2023-11-01) |
Primary citation | Hare, S.,Gupta, S.S.,Valkov, E.,Engelman, A.,Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464:232-236, 2010 Cited by PubMed: 20118915DOI: 10.1038/nature08784 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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