3S3O
Crystal structure of the Prototype Foamy Virus (PFV) N224H mutant intasome in complex with magnesium and Dolutegravir (S/GSK1349572)
Summary for 3S3O
Entry DOI | 10.2210/pdb3s3o/pdb |
Related | 3L2U 3OY9 3OYA 3OYB 3OYK 3OYL 3OYM 3OYN 3S3M 3S3N |
Descriptor | PFV integrase, HEXANE-1,6-DIOL, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', ... (11 entities in total) |
Functional Keywords | protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, recombination-inhibitor-dna complex, recombination/inhibitor/dna |
Biological source | Human spumaretrovirus (SFVcpz(hu), Human foamy virus) |
Cellular location | Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350 |
Total number of polymer chains | 4 |
Total formula weight | 101317.84 |
Authors | Hare, S.,Cherepanov, P. (deposition date: 2011-05-18, release date: 2011-07-13, Last modification date: 2023-09-13) |
Primary citation | Hare, S.,Smith, S.J.,Metifiot, M.,Jaxa-Chamiec, A.,Pommier, Y.,Hughes, S.H.,Cherepanov, P. Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572). Mol.Pharmacol., 80:565-572, 2011 Cited by PubMed: 21719464DOI: 10.1124/mol.111.073189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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