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3OYB

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI MK2048

Summary for 3OYB
Entry DOI10.2210/pdb3oyb/pdb
Related3DLR 3L2Q 3L2R 3L2U 3L2V 3L2W 3OY9 3OYA 3OYC 3OYD 3OYE 3OYF 3OYG 3OYH 3OYI 3OYJ 3OYK 3OYL 3OYM 3OYN
DescriptorPFV integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total)
Functional Keywordsprotein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, dna-binding protein-dna complex, viral protein-dna complex, viral protein/dna
Biological sourceHuman spumaretrovirus (SFVcpz(hu))
More
Cellular locationIntegrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
Total number of polymer chains4
Total formula weight101122.32
Authors
Hare, S.,Cherepanov, P. (deposition date: 2010-09-23, release date: 2010-11-17, Last modification date: 2023-09-06)
Primary citationHare, S.,Vos, A.M.,Clayton, R.F.,Thuring, J.W.,Cummings, M.D.,Cherepanov, P.
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA, 107:20057-20062, 2010
Cited by
PubMed: 21030679
DOI: 10.1073/pnas.1010246107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.54 Å)
Structure validation

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