3OY9

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese at 2.55 resolution

Replaces:  3L2S

Summary for 3OY9

• Entry DOI: 10.2210/pdb3oy9/pdb
• Related: 3DLR 3L2Q 3L2R 3L2U 3L2V 3L2W 3OYA 3OYB 3OYC 3OYD 3OYE 3OYF 3OYG 3OYH 3OYI 3OYJ 3OYK 3OYL 3OYM 3OYN
• Descriptor: PFV integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (9 entities in total)
• Functional Keywords: protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, dna-binding protein-dna complex, viral protein-dna complex, viral protein/dna
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Cellular location: Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350
• Total number of polymer chains: 4
• Total formula weight: 100752.35

Authors

Hare, S.,Cherepanov, P. (deposition date: 2010-09-23, release date: 2010-10-20, Last modification date: 2023-09-06)

• Primary citation: Hare, S.,Gupta, S.S.,Valkov, E.,Engelman, A.,Cherepanov, P.; Retroviral intasome assembly and inhibition of DNA strand transfer.; Nature, 464:232-236, 2010; PubMed: 20118915; DOI: 10.1038/nature08784

Experimental method

X-RAY DIFFRACTION (2.55 Å)