3RLY
Human Thrombin in complex with MI329
Summary for 3RLY
Entry DOI | 10.2210/pdb3rly/pdb |
Related | 1K1O 2ZQ1 3F68 3P17 3QTO 3RLW 3RM0 3RM2 3RML 3RMM 3RMN 3RMO |
Related PRD ID | PRD_001100 |
Descriptor | Thrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-2, ... (9 entities in total) |
Functional Keywords | serine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, hirudin, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 36936.83 |
Authors | |
Primary citation | Biela, A.,Sielaff, F.,Terwesten, F.,Heine, A.,Steinmetzer, T.,Klebe, G. Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55:6094-6110, 2012 Cited by PubMed: 22612268DOI: 10.1021/jm300337q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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