Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3RLW

Human Thrombin in complex with MI328

Summary for 3RLW
Entry DOI10.2210/pdb3rlw/pdb
Related1K1O 1K22 2ZQ1 3F68 3P17 3QTO 3RLY 3RM0 3RM2 3RML 3RMM 3RMN 3RMO
Related PRD IDPRD_001087
DescriptorThrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-2, ... (9 entities in total)
Functional Keywordsserine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, hirudin, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains3
Total formula weight36635.42
Authors
Biela, A.,Heine, A.,Klebe, G. (deposition date: 2011-04-20, release date: 2012-04-25, Last modification date: 2023-12-06)
Primary citationBiela, A.,Sielaff, F.,Terwesten, F.,Heine, A.,Steinmetzer, T.,Klebe, G.
Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect
J.Med.Chem., 55:6094-6110, 2012
Cited by
PubMed: 22612268
DOI: 10.1021/jm300337q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon