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3RM2

Human Thrombin in complex with MI003

Summary for 3RM2
Entry DOI10.2210/pdb3rm2/pdb
Related1K1O 2ZQ1 3QTO 3RLW 3RLY 3RM0 3RML 3RMM 3RMN 3RMO
Related PRD IDPRD_000806
DescriptorThrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-2, ... (9 entities in total)
Functional Keywordsserine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, hirudin, blood, glycosylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total formula weight36639.50
Authors
Biela, A.,Heine, A.,Klebe, G. (deposition date: 2011-04-20, release date: 2012-04-25, Last modification date: 2023-12-06)
Primary citationBiela, A.,Sielaff, F.,Terwesten, F.,Heine, A.,Steinmetzer, T.,Klebe, G.
Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect
J.Med.Chem., 55:6094-6110, 2012
Cited by
PubMed: 22612268
DOI: 10.1021/jm300337q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.23 Å)
Structure validation

217705

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