3P17
Thrombin Inhibition by Pyridin Derivatives
Summary for 3P17
Entry DOI | 10.2210/pdb3p17/pdb |
Related | 1K1O 1K22 2ZQ1 3EQ0 3F68 |
Related PRD ID | PRD_001112 |
Descriptor | thrombin light chain, thrombin heavy chain, Hirudin variant-2, ... (8 entities in total) |
Functional Keywords | serine protease, kringle, disulfide bonds, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, thrombin inhibitor, glycosylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 36125.90 |
Authors | |
Primary citation | Biela, A.,Khayat, M.,Tan, H.,Kong, J.,Heine, A.,Hangauer, D.,Klebe, G. Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin. J.Mol.Biol., 418:350-366, 2012 Cited by PubMed: 22366545DOI: 10.1016/j.jmb.2012.01.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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