3P6Z

Structural basis of thrombin mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction

Summary for 3P6Z

Entry DOI	10.2210/pdb3p6z/pdb
Related	1DX5 1E0F 1NU7 1PPB 2PW8 3LU9 3P70
Related PRD ID	PRD_000020
Descriptor	Thrombin light chain, Thrombin heavy chain, Coagulation factor V, ... (9 entities in total)
Functional Keywords	trypsin-like serine proteinase, blood coagulation, n-glycosylation, blood plasma, ppack, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	86319.21
Authors	Corral-Rodriguez, M.A.,Bock, P.E.,Hernandez-Carvajal, E.,Gutierrez-Gallego, R.,Fuentes-Prior, P. (deposition date: 2010-10-11, release date: 2011-06-15, Last modification date: 2024-03-13)
Primary citation	Corral-Rodriguez, M.A.,Bock, P.E.,Hernandez-Carvajal, E.,Gutierrez-Gallego, R.,Fuentes-Prior, P. Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction. Blood, 117:7164-7173, 2011 Cited by PubMed: 21555742 DOI: 10.1182/blood-2010-10-315309 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation