3P70
Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction
Summary for 3P70
Entry DOI | 10.2210/pdb3p70/pdb |
Related | 1DX5 1E0F 1NU7 1PPB 2PW8 3LU9 3P6Z |
Descriptor | HUMAN ALPHA-THROMBIN, LIGHT CHAIN, HUMAN ALPHA-THROMBIN, HEAVY CHAIN, HUMAN FACTOR V, A2-B DOMAIN LINKER, ... (9 entities in total) |
Functional Keywords | trypsin-like serine proteinase, blood coagulation, n-glycosylation, blood plasma, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 171547.98 |
Authors | Corral-Rodriguez, M.A.,Bock, P.E.,Hernandez-Carvajal, E.,Gutierrez-Gallego, R.,Fuentes-Prior, P. (deposition date: 2010-10-11, release date: 2011-09-28, Last modification date: 2023-09-06) |
Primary citation | Corral-Rodriguez, M.A.,Bock, P.E.,Hernandez-Carvajal, E.,Gutierrez-Gallego, R.,Fuentes-Prior, P. Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction. Blood, 117:7164-7173, 2011 Cited by PubMed: 21555742DOI: 10.1182/blood-2010-10-315309 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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