3LU9
Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1
Summary for 3LU9
Entry DOI | 10.2210/pdb3lu9/pdb |
Related | 1SHH |
Descriptor | Prothrombin, Proteinase-activated receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | serine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, zymogen, cell membrane, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 76841.28 |
Authors | Gandhi, P.S.,Chen, Z.,Di Cera, E. (deposition date: 2010-02-17, release date: 2010-03-16, Last modification date: 2023-09-06) |
Primary citation | Gandhi, P.S.,Chen, Z.,Di Cera, E. Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. J.Biol.Chem., 285:15393-15398, 2010 Cited by PubMed: 20236938DOI: 10.1074/jbc.M110.115337 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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