3P70

Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0007596	biological_process	blood coagulation
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005509	molecular_function	calcium ion binding
B	0006508	biological_process	proteolysis
B	0007596	biological_process	blood coagulation
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0007596	biological_process	blood coagulation
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005509	molecular_function	calcium ion binding
D	0006508	biological_process	proteolysis
D	0007596	biological_process	blood coagulation
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005576	cellular_component	extracellular region
E	0006508	biological_process	proteolysis
E	0007596	biological_process	blood coagulation
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005509	molecular_function	calcium ion binding
F	0006508	biological_process	proteolysis
F	0007596	biological_process	blood coagulation
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005576	cellular_component	extracellular region
G	0006508	biological_process	proteolysis
G	0007596	biological_process	blood coagulation
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
B	LEU402-CYS407

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
B	ASP562-VAL573

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Cleavage; by activated protein C => ECO:0000269|PubMed:7989361

Chain	Residue	Details
M	ARG679
N	ARG679
O	ARG679
P	ARG679
D	ASP462
D	SER568
F	HIS406
F	ASP462
F	SER568
H	HIS406
H	ASP462
H	SER568

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Cleavage; by thrombin => ECO:0000269|PubMed:3110773

Chain	Residue	Details
M	ARG709
N	ARG709
O	ARG709
P	ARG709

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site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Sulfotyrosine => ECO:0000255

Chain	Residue	Details
M	TYR665
M	TYR696
M	TYR698
N	TYR665
N	TYR696
N	TYR698
O	TYR665
O	TYR696
O	TYR698
P	TYR665
P	TYR696
P	TYR698

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