3P6Z
Structural basis of thrombin mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, G) | Thrombin light chain | polymer | 36 | 4096.5 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II, Thrombin light chain |
| 2 | B, E (B, H) | Thrombin heavy chain | polymer | 259 | 29780.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II, Thrombin heavy chain |
| 3 | C, F (C, I) | Coagulation factor V | polymer | 71 | 8391.9 | 2 | UniProt (P12259) | Homo sapiens (human) | Activated protein C cofactor |
| 4 | G, J, K, P, S... (A, B, G, H) | SODIUM ION | non-polymer | 23.0 | 9 | Chemie (NA) | |||
| 5 | H, Q (B, H) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 2 | BIRD (PRD_000020) Chemie (0G6) | |||
| 6 | I, R (B, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | L, M, N (B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 8 | O (B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 9 | AA, BA, CA, X, Y... (G, H, I, A, B...) | water | water | 18.0 | 505 | Chemie (HOH) |
Sequence modifications
C, I: 657 - 709 (UniProt: P12259)
| PDB | External Database | Details |
|---|---|---|
| Ala 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
| His 642 | - | expression tag |
| His 643 | - | expression tag |
| His 644 | - | expression tag |
| His 645 | - | expression tag |
| Val 646 | - | expression tag |
| Gly 647 | - | expression tag |
| Thr 648 | - | expression tag |
| Trp 649 | - | expression tag |
| Glu 650 | - | expression tag |
| Asn 651 | - | expression tag |
| Leu 652 | - | expression tag |
| Tyr 653 | - | expression tag |
| Phe 654 | - | expression tag |
| Gln 655 | - | expression tag |
| Ser 656 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 84537.4 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1781.8 | |
| All* | Total formula weight | 86319.2 |
