3OJ8

Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain

3OJ8 の概要

• エントリーDOI: 10.2210/pdb3oj8/pdb
• 関連するPDBエントリー: 2vya 2wap 2wj1 2wj2 3k7f 3lj6
• 分子名称: Fatty-acid amide hydrolase 1, (S)-[(2S)-6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl](5-pyridin-2-yl-1,3-oxazol-2-yl)methanol, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, faah, oxazole, enantiomer, serine hydrolase, membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127055.69

構造登録者

Mileni, M.,Stevens, R.C.,Boger, D.L. (登録日: 2010-08-20, 公開日: 2011-07-06, 最終更新日: 2011-07-13)

• 主引用文献: Ezzili, C.,Mileni, M.,McGlinchey, N.,Long, J.Z.,Kinsey, S.G.,Hochstatter, D.G.,Stevens, R.C.,Lichtman, A.H.,Cravatt, B.F.,Bilsky, E.J.,Boger, D.L.; alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain; J.Med.Chem., 54:2805-2822, 2011; PubMed: 21428410; DOI: 10.1021/jm101597x

実験手法

X-RAY DIFFRACTION (1.9 Å)