3OJ8
Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fatty-acid amide hydrolase 1 | polymer | 573 | 63111.7 | 2 | UniProt (P97612) Pfam (PF01425) In PDB | Rattus norvegicus (brown rat rat rats) | Oleamide hydrolase 1, Anandamide amidohydrolase 1 |
2 | A, B | (S)-[(2S)-6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl](5-pyridin-2-yl-1,3-oxazol-2-yl)methanol | non-polymer | 398.5 | 2 | Chemie (OJ8) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | water | water | 18.0 | 985 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 579 (UniProt: P97612)
PDB | External Database | Details |
---|---|---|
Met 7 | - | EXPRESSION TAG |
Gly 8 | - | EXPRESSION TAG |
Ser 9 | - | EXPRESSION TAG |
Ser 10 | - | EXPRESSION TAG |
His 11 | - | EXPRESSION TAG |
His 12 | - | EXPRESSION TAG |
His 13 | - | EXPRESSION TAG |
His 14 | - | EXPRESSION TAG |
His 15 | - | EXPRESSION TAG |
His 16 | - | EXPRESSION TAG |
Ser 17 | - | EXPRESSION TAG |
Ser 18 | - | EXPRESSION TAG |
Gly 19 | - | EXPRESSION TAG |
Leu 20 | - | EXPRESSION TAG |
Val 21 | - | EXPRESSION TAG |
Pro 22 | - | EXPRESSION TAG |
Arg 23 | - | EXPRESSION TAG |
Gly 24 | - | EXPRESSION TAG |
Ser 25 | - | EXPRESSION TAG |
His 26 | - | EXPRESSION TAG |
Met 27 | - | EXPRESSION TAG |
Ala 28 | - | EXPRESSION TAG |
Ser 29 | - | EXPRESSION TAG |
Phe 192 | Leu 192 | ENGINEERED MUTATION |
Tyr 194 | Phe 194 | ENGINEERED MUTATION |
Thr 377 | Ala 377 | ENGINEERED MUTATION |
Asn 435 | Ser 435 | ENGINEERED MUTATION |
Val 491 | Ile 491 | ENGINEERED MUTATION |
Met 495 | Val 495 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 126223.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 832.4 | |
All* | Total formula weight | 127055.7 |