3OJ8

Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain

Summary for 3OJ8

Entry DOI	10.2210/pdb3oj8/pdb
Related	2vya 2wap 2wj1 2wj2 3k7f 3lj6
Descriptor	Fatty-acid amide hydrolase 1, (S)-[(2S)-6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl](5-pyridin-2-yl-1,3-oxazol-2-yl)methanol, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, faah, oxazole, enantiomer, serine hydrolase, membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	127055.69
Authors	Mileni, M.,Stevens, R.C.,Boger, D.L. (deposition date: 2010-08-20, release date: 2011-07-06, Last modification date: 2011-07-13)
Primary citation	Ezzili, C.,Mileni, M.,McGlinchey, N.,Long, J.Z.,Kinsey, S.G.,Hochstatter, D.G.,Stevens, R.C.,Lichtman, A.H.,Cravatt, B.F.,Bilsky, E.J.,Boger, D.L. alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain J.Med.Chem., 54:2805-2822, 2011 Cited by PubMed: 21428410 DOI: 10.1021/jm101597x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation