2WJ2
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole
Summary for 2WJ2
Entry DOI | 10.2210/pdb2wj2/pdb |
Related | 1MT5 2VYA 2WAP 2WJ1 |
Descriptor | FATTY ACID AMIDE HYDROLASE 1, 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | endoplasmic reticulum, monotopic membrane protein, membrane, hydrolase, transmembrane, phosphoprotein, covalent reversible inhibitors, fatty acid amide hydrolase, golgi apparatus, alpha-ketooxazole |
Biological source | RATTUS NORVEGICUS (RAT) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
Total number of polymer chains | 2 |
Total formula weight | 126963.63 |
Authors | Mileni, M.,Garfunkle, J.,DeMartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. (deposition date: 2009-05-19, release date: 2009-09-15, Last modification date: 2023-12-13) |
Primary citation | Mileni, M.,Garfunkle, J.,Demartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures. J.Am.Chem.Soc., 131:10497-, 2009 Cited by PubMed: 19722626DOI: 10.1021/JA902694N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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