3K2U

Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40

Summary for 3K2U

Entry DOI	10.2210/pdb3k2u/pdb
Related	1YBW 1YC0 2R0K 2R0L
Descriptor	Hepatocyte growth factor activator long chain, Hepatocyte growth factor activator short chain, Antibody, Fab fragment, Heavy Chain, ... (6 entities in total)
Functional Keywords	serine protease, allosteric inhibitor, antibody, egf-like domain, glycoprotein, fab complex, hydrolase, disulfide bond, kringle, protease, secreted, zymogen, hydrolase-immune system complex, hydrolase/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	79379.04
Authors	Ganesan, R.,Eigenbrot, C.,Shia, S. (deposition date: 2009-09-30, release date: 2009-12-15, Last modification date: 2023-09-06)
Primary citation	Ganesan, R.,Eigenbrot, C.,Wu, Y.,Liang, W.C.,Shia, S.,Lipari, M.T.,Kirchhofer, D. Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure, 17:1614-1624, 2009 Cited by PubMed: 20004165 DOI: 10.1016/j.str.2009.09.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation