2R0K
Protease domain of HGFA with inhibitor Fab58
Summary for 2R0K
Entry DOI | 10.2210/pdb2r0k/pdb |
Related | 1YBW 1YC0 2R0L |
Descriptor | Hepatocyte growth factor activator, antibody light chain of Fab58, antibody heavy chain of Fab58, Fab portion only (3 entities in total) |
Functional Keywords | serine protease, antibody, inhibitor, egf-like domain, glycoprotein, hydrolase, kringle, secreted, zymogen, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: Q04756 |
Total number of polymer chains | 3 |
Total formula weight | 77861.43 |
Authors | Eigenbrot, C.,Shia, S. (deposition date: 2007-08-20, release date: 2007-12-25, Last modification date: 2023-08-30) |
Primary citation | Wu, Y.,Eigenbrot, C.,Liang, W.C.,Stawicki, S.,Shia, S.,Fan, B.,Ganesan, R.,Lipari, M.T.,Kirchhofer, D. Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104:19784-19789, 2007 Cited by PubMed: 18077410DOI: 10.1073/pnas.0708251104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.51 Å) |
Structure validation
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