2R0L
Short Form HGFA with Inhibitory Fab75
Summary for 2R0L
Entry DOI | 10.2210/pdb2r0l/pdb |
Related | 1YBW 1YC0 2R0K |
Descriptor | antibody light chain, antibody heavy chain, Fab portion only, Hepatocyte growth factor activator, ... (6 entities in total) |
Functional Keywords | serine protease, antibody, allosteric inhibitor, egf-like domain, glycoprotein, hydrolase, kringle, secreted, zymogen, immune system |
Biological source | Homo sapiens, Synthetic construct More |
Total number of polymer chains | 4 |
Total formula weight | 78079.55 |
Authors | Eigenbrot, C.,Shia, S. (deposition date: 2007-08-20, release date: 2007-12-25, Last modification date: 2023-08-30) |
Primary citation | Wu, Y.,Eigenbrot, C.,Liang, W.C.,Stawicki, S.,Shia, S.,Fan, B.,Ganesan, R.,Lipari, M.T.,Kirchhofer, D. Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104:19784-19789, 2007 Cited by PubMed: 18077410DOI: 10.1073/pnas.0708251104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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