3K2U

Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor activator long chain	polymer	257	27982.6	1	UniProt (Q04756) Pfam (PF00089) In PDB	Homo sapiens (human)	HGF activator, HGFA
2	B	Hepatocyte growth factor activator short chain	polymer	35	3962.7	1	UniProt (Q04756) In PDB	Homo sapiens (human)	HGF activator, HGFA
3	H	Antibody, Fab fragment, Heavy Chain	polymer	225	23770.6	1		Homo sapiens (human)
4	L	Antibody, Fab fragment, Light Chain	polymer	214	23238.7	1		Homo sapiens (human)
5	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6		water	water		18.0	168	Chemie (HOH)

Sequence modifications

A: 16 - 252 (UniProt: Q04756)

PDB	External Database	Details
Ala 253	-	expression tag
Ala 254	-	expression tag
Ala 255	-	expression tag
His 256	-	expression tag
His 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	78954.6
Branched	Number of molecules	1
	Total formula weight	424.4
All*	Total formula weight	79379.0

*Water molecules are not included.