3K2U
Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor activator long chain | polymer | 257 | 27982.6 | 1 | UniProt (Q04756) Pfam (PF00089) | Homo sapiens (human) | HGF activator, HGFA |
| 2 | B (B) | Hepatocyte growth factor activator short chain | polymer | 35 | 3962.7 | 1 | UniProt (Q04756) | Homo sapiens (human) | HGF activator, HGFA |
| 3 | C (H) | Antibody, Fab fragment, Heavy Chain | polymer | 225 | 23770.6 | 1 | Homo sapiens (human) | ||
| 4 | D (L) | Antibody, Fab fragment, Light Chain | polymer | 214 | 23238.7 | 1 | Homo sapiens (human) | ||
| 5 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F, G, H, I (A, B, H, L) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
A: 16 - 252 (UniProt: Q04756)
| PDB | External Database | Details |
|---|---|---|
| Ala 253 | - | expression tag |
| Ala 254 | - | expression tag |
| Ala 255 | - | expression tag |
| His 256 | - | expression tag |
| His 257 | - | expression tag |
| His 258 | - | expression tag |
| His 259 | - | expression tag |
| His 260 | - | expression tag |
| His 261 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 78954.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| All* | Total formula weight | 79379.0 |
