3H4V
Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1
Replaces: 2P8KSummary for 3H4V
Entry DOI | 10.2210/pdb3h4v/pdb |
Related | 1e92 1p33 1w0c 2bf7 2bfa 2bfm 2qhx |
Descriptor | Pteridine reductase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, ... (4 entities in total) |
Functional Keywords | short-chain reductase, leishmania, trypanosoma, ptr1, inhibitor, oxidoreductase, methotrexate resistance, nadp |
Biological source | Leishmania major |
Total number of polymer chains | 8 |
Total formula weight | 252963.62 |
Authors | Mcluskey, K.,Gibellini, F.,Hunter, W.N. (deposition date: 2009-04-21, release date: 2009-05-05, Last modification date: 2023-11-01) |
Primary citation | Cavazzuti, A.,Paglietti, G.,Hunter, W.N.,Gamarro, F.,Piras, S.,Loriga, M.,Allecca, S.,Corona, P.,McLuskey, K.,Tulloch, L.,Gibellini, F.,Ferrari, S.,Costi, M.P. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development Proc.Natl.Acad.Sci.USA, 105:1448-1453, 2008 Cited by PubMed: 18245389DOI: 10.1073/pnas.0704384105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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