2BF7
Leishmania major pteridine reductase 1 in complex with NADP and biopterin
Summary for 2BF7
Entry DOI | 10.2210/pdb2bf7/pdb |
Related | 1E7W 1E92 1W0C 2BFA 2BFM 2BFO 2BFP |
Descriptor | PTERIDINE REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7,8-DIHYDROBIOPTERIN, ... (5 entities in total) |
Functional Keywords | pteridine reductase, trypanosomatids, drug resistance, pterin, salvage, short-chain dehydrogenase/reductase, methotrexate resistance, nadp, oxidoreductase |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 4 |
Total formula weight | 126003.20 |
Authors | Schuettelkopf, A.W.,Hunter, W.N. (deposition date: 2004-12-06, release date: 2005-08-31, Last modification date: 2023-12-13) |
Primary citation | Schuettelkopf, A.W.,Hardy, L.W.,Beverley, S.M.,Hunter, W.N. Structures of Leishmania Major Pteridine Reductase Complexes Reveal the Active Site Features Important for Ligand Binding and to Guide Inhibitor Design J.Mol.Biol., 352:105-, 2005 Cited by PubMed: 16055151DOI: 10.1016/J.JMB.2005.06.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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