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2BF7

Leishmania major pteridine reductase 1 in complex with NADP and biopterin

Functional Information from GO Data
ChainGOidnamespacecontents
A0004155molecular_function6,7-dihydropteridine reductase activity
A0005829cellular_componentcytosol
A0006729biological_processtetrahydrobiopterin biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0031427biological_processresponse to methotrexate
A0047040molecular_functionpteridine reductase activity
B0004155molecular_function6,7-dihydropteridine reductase activity
B0005829cellular_componentcytosol
B0006729biological_processtetrahydrobiopterin biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0031427biological_processresponse to methotrexate
B0047040molecular_functionpteridine reductase activity
C0004155molecular_function6,7-dihydropteridine reductase activity
C0005829cellular_componentcytosol
C0006729biological_processtetrahydrobiopterin biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0031427biological_processresponse to methotrexate
C0047040molecular_functionpteridine reductase activity
D0004155molecular_function6,7-dihydropteridine reductase activity
D0005829cellular_componentcytosol
D0006729biological_processtetrahydrobiopterin biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0031427biological_processresponse to methotrexate
D0047040molecular_functionpteridine reductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues31
DetailsBINDING SITE FOR RESIDUE NAP A1289
ChainResidue
AARG17
ALEU66
AASN109
AALA110
ASER111
ASER112
AASP142
AMET179
AVAL180
AASP181
ATYR194
ALEU18
ALYS198
APRO224
AGLY225
ALEU226
ASER227
AHBI1290
AHOH2003
AHOH2004
AHOH2006
AHOH2077
AHIS36
AHOH2078
AHOH2079
ATYR37
AHIS38
AARG39
ASER40
AALA64
AASP65

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE HBI A1290
ChainResidue
AARG17
ASER111
APHE113
AASP181
ATYR194
ALEU226
ANAP1289
DHOH2047

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A1291
ChainResidue
AGLY199
AGLU202
AARG206
BGLY199
BGLU202
BARG206

site_idAC4
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAP B1289
ChainResidue
BARG17
BLEU18
BHIS36
BTYR37
BHIS38
BARG39
BSER40
BALA64
BASP65
BLEU66
BASN109
BALA110
BSER111
BSER112
BASP142
BMET179
BVAL180
BASP181
BTYR194
BLYS198
BPRO224
BGLY225
BLEU226
BSER227
BHBI1290
BHOH2027
BHOH2052
BHOH2053

site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HBI B1290
ChainResidue
BARG17
BSER111
BPHE113
BASP181
BTYR194
BLEU226
BLEU229
BNAP1289
BHOH2054
CHOH2070

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO B1291
ChainResidue
AASN68
BASN68
BHOH2055

site_idAC7
Number of Residues30
DetailsBINDING SITE FOR RESIDUE NAP C1289
ChainResidue
CSER112
CASP142
CMET179
CVAL180
CASP181
CTYR194
CLYS198
CPRO224
CGLY225
CLEU226
CSER227
CHBI1290
CHOH2028
CHOH2072
CHOH2073
CHOH2074
CHOH2075
CARG17
CLEU18
CHIS36
CTYR37
CHIS38
CARG39
CSER40
CALA64
CASP65
CLEU66
CASN109
CALA110
CSER111

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE HBI C1290
ChainResidue
CARG17
CSER111
CPHE113
CTYR194
CLEU229
CNAP1289
CHOH2076
CHOH2077

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO C1291
ChainResidue
AASN52
APRO56
AASN57
CASN52
CASN57
CHOH2078
CHOH2079

site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO C1292
ChainResidue
CASN68
DASN68

site_idBC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP D1289
ChainResidue
DARG17
DLEU18
DHIS38
DARG39
DSER40
DALA64
DASP65
DLEU66
DASN109
DALA110
DSER111
DSER112
DASP142
DMET179
DVAL180
DASP181
DTYR194
DLYS198
DPRO224
DGLY225
DLEU226
DSER227
DHBI1290
DHOH2049
DHOH2050
DHOH2051
DHOH2052

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE HBI D1290
ChainResidue
DARG17
DSER111
DPHE113
DTYR194
DLEU226
DLEU229
DNAP1289
DHOH2052

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO D1291
ChainResidue
DARG170
DGLY171
DTHR172
DTYR174
DLEU215
DGLN216
DHOH2054
DHOH2055

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. DamtnqpllgYtiYTMAKGALeGLTrSAA
ChainResidueDetails
AASP181-ALA209

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ATYR194
BTYR194
CTYR194
DTYR194

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG17
BARG17
CARG17
DARG17

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11373620
ChainResidueDetails
ASER175
BSER175
CSER175
DSER175

221051

PDB entries from 2024-06-12

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