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3E7B

Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin inhibitor Tautomycin

Summary for 3E7B
Entry DOI10.2210/pdb3e7b/pdb
Related1FJM 1IT6 1JK7 2BCD 3E7A
DescriptorSerine/threonine-protein phosphatase PP1-alpha catalytic subunit, MANGANESE (II) ION, (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10R)-10-{(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(3S)-3-methyl-4-oxopentyl]-1,7-dioxaspiro[5.5]undec-2-yl}-3,7-dihydroxy-2-methoxy-6-methyl-1-(1-methylethyl)-5-oxoundecyl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, ... (8 entities in total)
Functional Keywordsprotein phosphatase 1, tautomycin, molecular toxin, carbohydrate metabolism, cell cycle, cell division, glycogen metabolism, hydrolase, iron, manganese, metal-binding, phosphoprotein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P62136
Total number of polymer chains2
Total formula weight70516.64
Authors
Kelker, M.S.,Page, R.,Peti, W. (deposition date: 2008-08-18, release date: 2008-11-04, Last modification date: 2023-08-30)
Primary citationKelker, M.S.,Page, R.,Peti, W.
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
J.Mol.Biol., 385:11-21, 2009
Cited by
PubMed: 18992256
DOI: 10.1016/j.jmb.2008.10.053
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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