3E7B
Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin inhibitor Tautomycin
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 400 |
| Chain | Residue |
| A | ASP64 |
| A | HIS66 |
| A | ASP92 |
| A | MN401 |
| A | HOH752 |
| A | HOH759 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | HIS248 |
| A | MN400 |
| A | HOH759 |
| A | ASP92 |
| A | ASN124 |
| A | HIS173 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE E7B A 500 |
| Chain | Residue |
| A | ARG96 |
| A | CYS127 |
| A | ILE130 |
| A | TYR134 |
| A | VAL195 |
| A | PRO196 |
| A | ASP197 |
| A | ASP220 |
| A | ARG221 |
| A | GLY222 |
| A | HIS248 |
| A | GLN249 |
| A | VAL250 |
| A | TYR272 |
| A | PHE276 |
| A | HOH516 |
| A | HOH540 |
| A | HOH595 |
| A | HOH602 |
| A | HOH614 |
| A | HOH665 |
| A | HOH735 |
| A | HOH752 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | GLY215 |
| A | GLY228 |
| A | ALA229 |
| A | GLU230 |
| A | VAL231 |
| A | HOH705 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | GLN49 |
| A | PRO50 |
| A | LEU53 |
| A | GLU54 |
| A | GLU116 |
| A | HOH660 |
| A | HOH746 |
| A | HOH777 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 502 |
| Chain | Residue |
| A | PRO82 |
| A | SER85 |
| A | ASN117 |
| A | PHE118 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AZI A 2 |
| Chain | Residue |
| A | GLN249 |
| A | GLU256 |
| A | HOH548 |
| A | HOH783 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AZI A 503 |
| Chain | Residue |
| A | PHE258 |
| A | ALA259 |
| A | LYS260 |
| A | ARG261 |
| A | HOH768 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AZI A 504 |
| Chain | Residue |
| A | LEU47 |
| A | MET190 |
| A | ARG191 |
| A | HOH592 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AZI A 505 |
| Chain | Residue |
| A | GLU252 |
| A | HOH696 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 400 |
| Chain | Residue |
| B | ASP64 |
| B | HIS66 |
| B | ASP92 |
| B | MN401 |
| B | HOH699 |
| B | HOH700 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | ASP92 |
| B | ASN124 |
| B | HIS173 |
| B | HIS248 |
| B | MN400 |
| B | HOH700 |
| site_id | BC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE E7B B 500 |
| Chain | Residue |
| B | HOH527 |
| B | HOH534 |
| B | HOH569 |
| B | HOH588 |
| B | ASP10 |
| B | ARG96 |
| B | LYS113 |
| B | TYR114 |
| B | CYS127 |
| B | SER129 |
| B | ILE130 |
| B | VAL195 |
| B | PRO196 |
| B | TRP206 |
| B | ASP220 |
| B | ARG221 |
| B | GLY222 |
| B | VAL223 |
| B | HIS248 |
| B | GLN249 |
| B | VAL250 |
| B | TYR272 |
| B | PHE276 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AZI B 2 |
| Chain | Residue |
| B | GLU252 |
| B | ASP277 |
| B | ASN278 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AZI B 501 |
| Chain | Residue |
| B | LEU47 |
| B | MET190 |
| B | ARG191 |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU121-GLU126 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aui |
| Chain | Residue | Details |
| A | ASP95 | |
| A | HIS125 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aui |
| Chain | Residue | Details |
| B | ASP95 | |
| B | HIS125 |
