3E7B
Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin inhibitor Tautomycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | polymer | 299 | 34162.1 | 2 | UniProt (P62136) Pfam (PF16891) Pfam (PF00149) In PDB | Homo sapiens (Human) | PP-1A |
| 2 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 3 | A, B | (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10R)-10-{(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(3S)-3-methyl-4-oxopentyl]-1,7-dioxaspiro[5.5]undec-2-yl}-3,7-dihydroxy-2-methoxy-6-methyl-1-(1-methylethyl)-5-oxoundecyl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid | non-polymer | 785.0 | 2 | Chemie (E7B) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | A, B | AZIDE ION | non-polymer | 42.0 | 6 | Chemie (AZI) | |||
| 8 | water | water | 18.0 | 487 | Chemie (HOH) |
Sequence modifications
A, B: 7 - 300 (UniProt: P62136)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68324.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2192.3 | |
| All* | Total formula weight | 70516.6 |
