3E7A

Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin Nodularin-R

Summary for 3E7A

Entry DOI	10.2210/pdb3e7a/pdb
Related	1FJM 1IT6 1JK7 2BCD 3E7B
Related PRD ID	PRD_000214
Descriptor	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, nodularin R, MANGANESE (II) ION, ... (8 entities in total)
Functional Keywords	carbohydrate metabolism, cell cycle, cell division, glycogen metabolism, hydrolase, iron, manganese, metal-binding, phosphoprotein, protein phosphatase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: P62136
Total number of polymer chains	4
Total formula weight	72418.71
Authors	Kelker, M.S.,Page, R.,Peti, W. (deposition date: 2008-08-18, release date: 2008-11-04, Last modification date: 2023-11-15)
Primary citation	Kelker, M.S.,Page, R.,Peti, W. Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors J.Mol.Biol., 385:11-21, 2009 Cited by PubMed: 18992256 DOI: 10.1016/j.jmb.2008.10.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation