2YC0

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE

2YC0 の概要

• エントリーDOI: 10.2210/pdb2yc0/pdb
• 関連するPDBエントリー: 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YDE
• 分子名称: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, (2R)-2-hydroxypentanedioic acid, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, dioxygenase, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41475.04

構造登録者

Chowdhury, R.,Clifton, I.J.,Schofield, C.J. (登録日: 2011-03-10, 公開日: 2011-03-30, 最終更新日: 2023-12-20)

• 主引用文献: Chowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.; The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.; EMBO Rep., 12:463-469, 2011; PubMed: 21460794; DOI: 10.1038/embor.2011.43

実験手法

X-RAY DIFFRACTION (2.15 Å)