2Y62

Crystal structure of Leishmanial E65Q-TIM complexed with R-Glycidol phosphate

Summary for 2Y62

• Entry DOI: 10.2210/pdb2y62/pdb
• Related: 1AMK 1IF2 1N55 1QDS 2VXN 2Y61 2Y63
• Descriptor: TRIOSEPHOSPHATE ISOMERASE SYNONYM TRIOSE-PHOSPHATE ISOMERASE, TIM, SN-GLYCEROL-3-PHOSPHATE, SN-GLYCEROL-1-PHOSPHATE, ... (5 entities in total)
• Functional Keywords: isomerase, fatty acid biosynthesis, transition state analogue, glycolysis, pentose shunt, gluconeogenesis, enzyme-ligand complex
• Biological source: LEISHMANIA MEXICANA
• Total number of polymer chains: 1
• Total formula weight: 27736.57

Authors

Venkatesan, R.,Alahuhta, M.,Pihko, P.M.,Wierenga, R.K. (deposition date: 2011-01-19, release date: 2011-12-14, Last modification date: 2023-12-20)

• Primary citation: Venkatesan, R.,Alahuhta, M.,Pihko, P.M.,Wierenga, R.K.; High Resolution Crystal Structures of Triosephosphate Isomerase Complexed with its Suicide Inhibitors: The Conformational Flexibility of the Catalytic Glutamate in its Closed, Liganded Active Site.; Protein Sci., 20:1387-, 2011; PubMed: 21633986; DOI: 10.1002/PRO.667

Experimental method

X-RAY DIFFRACTION (1.08 Å)